HEPCIDIN DEFICIENCY IN MICE IMPAIRS WHITE ADIPOSE TISSUE BROWNING POSSIBLY DUE TO A DEFECT IN DE NOVO ADIPOGENESIS

Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis

Abstract The role of iron in the Line Friends two major sites of adaptive thermogenesis, namely the beige inguinal (iWAT) and brown adipose tissues (BAT) has not been fully understood yet.Body iron levels and distribution is controlled by the iron regulatory peptide hepcidin.Here, we explored iron homeostasis and thermogenic activity in brown and b

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Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.

BackgroundIn breast cancers, only a minority of patients fully benefit from the different chemotherapy regimens currently in use.Identification of markers that could predict the response to a particular regimen would thus be critically important for patient care.In cell lines or animal models, tumor protein p53 (TP53) plays a critical role in modul

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Dengue: muscle biopsy findings in 15 patients

Dengue is known to produce a MEMORY BOOST syndrome involving muscles, tendons and joints.The hallmark of this syndrome is severe myalgia but includes fever, cutaneous rash, and headache.The neuromuscular aspects of this infection are outlined only in isolated reports, and the muscle histopathological features during myalgia have not been described.

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Improving sea surface temperature in a regional ocean model through refined sea surface temperature assimilation

Infrared (IR) and passive microwave (PMW) satellite sea surface temperature (SST) retrievals are valuable to assimilate into high-resolution regional ocean forecast models.Still, there are issues related to these SSTs that need to be addressed to achieve improved ocean forecasts.Firstly, satellite SST products tend to be Soapstone Carvings biased.A

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